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TSC2 forms a heterodimeric complex with TSC1 that suppresses the mTOR complex 1 (mTORC1) activity by inhibiting the small GTPase Rheb, an essential mTORC1 activator [263]

Briefly, tissue sections were incubated with primary antibodies at a suitable concentration at 4 C overnight

Emerging studies have linked deficient SAMe production and disruption in transmethylation pathways with delayed brain development and severe neuropsychiatric diseases [6]

RESULTS Descriptive data of the children included in the study are represented in Table 1