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High concentrations of 4HNE have been associated with different processes such as apoptosis, cell differentiation, altered gene expression and with several diseases correlated to redox imbalance such as neurodegenerative and cardiovascular diseases, metabolic syndrome, and cancer 15

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Br J Clin Pharmacol 90(11):29102919

Temperature proves the dominant factor affecting degradation rates - every 10C increase doubles degradation speed, making refrigeration at 2-8C essential for all reconstituted solutions and beneficial for extending powder shelf life beyond basic 12-18 month refrigerated baseline

10.1074/jbc.M109410200