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LA maintains the cellular antioxidant state indirectly through activating the NRF2 pathway, and the NRF2 pathway governs the expression of antioxidant genes (such as -glutamylcysteine synthetase (-GCL), NAD(P)H quinone oxidoreductase 1 (NQO-1), and superoxide dismutase (SOD)) for enhancing the cell's antioxidant capacity and anti-inflammatory response [34, 35]

Both reductive steps are catalysed by the enzyme dihydrofolate reductase

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Alpha-MSH and its C-terminal tripeptide KPV exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans , two pathogens directly implicated in eczema severity

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