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It is intended only for adult smokers

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One limitation of this study is that smoker and nonsmoker participants were treated differently: the smoker group was exposed to cigarettes whereas the nonsmoker group were not

They work by heating the e-liquid, which may contain a combination of nicotine, solvent carriers (glycerol, propylene and/or ethylene glycol) and any number of flavors and other chemicals, to a high enough temperature to create an aerosol, or "vapor, that is inhaled and exhaled

While previous studies have examined the public health implications of market authorization for e-cigarettes, HTPs, or hypothetical smoke-free tobacco products (15, 7, 10, 11, 17, 1921, 36) utilizing a two-product model, we present a more robust approach with a three-product model