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The peptides create several biological effects in cartilage tissue: They stimulate extracellular matrix macromolecule synthesis, including proteoglycans and type II collagen [3] They trigger chondrogenic proliferation and differentiation [3] They boost osteoblast activity while reducing osteoclast activity [3] These effects explain why collagen supplements protect cartilage in osteoarthritis and help repair it [3]

The scientific studies of these experimental drugs were never large enough or long enough to establish a clear safety profile, so all we are left with are vague reassurances from tiny studies and testimonials from YouTubers and TikTokers

Together, they build a fibrocartilaginous bridge across the fracture gap called a soft callus

MIC, minimum inhibitory concentration