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Funding This work was funded by NIH grant R21HD112772, R01HD111706, and USDA National Institute of Food and Agriculture, Hatch Project ILLU-538-949 to MD

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Clinical studies have shown that it can significantly increase thyroxine (T4) levels and decrease thyroid-stimulating hormone (TSH) in individuals with subclinical hypothyroidism, highlighting its therapeutic potential [231]

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Dihexa-treated rats quickly regained motor performance equivalent to sham-operated controls, and significantly surpassed those receiving a placebo