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Trends Cardiovasc Med 14:273281

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Safety Comes First: Screening and Risk Management Because Vitamin C operates as a pro-oxidant at high concentrations, providers must verify that patients are not G6PD deficient before injection

While the precise mechanism for the disruption of the ligand-binding interaction between these two proteins is not defined, the presence of an aggregation of GST monomers following oxidative stress implicates intermolecular disulfide bridge formation between available cysteine residues

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