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Efficacy depends on the supplement quality and individual metabolism
However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)
Research-only escalation preview This preview illustrates how study participants were escalated from lower starting doses up to their final weekly dose
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