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Neurology 40:767

Additionally, the proteasome has been identified as a viable target, with inhibitors like GNF6702 exhibiting broad-spectrum antiprotozoal activity against Leishmania species by selectively targeting the parasites proteasome without affecting host cells (Khare et al., 2016)

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The RT prototypes without the carboxylic acid groups, such as RT-NH 2 and TQG-CN, are fairly hydrophobic and cannot distribute in the nucleus, which is a hallmark of protein binding for fluorescent probes (Fig