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With the consistent application of the peptide alone, this skin-healing evidence (Seiwerth et al., 1997

High dose intravenous colistin methanesulfonate therapy is associated with high rates of nephrotoxicity

It remains an open question why for example cattle and dogs presumably lost their complete set of -defensin genes while in the horse the number increased extensively

The major concern is the 4-OH-E1 route catalyzed by CYP1B1