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The current study revealed a high Fe concentration in the liver of rats with PCOS
The complex pathophysiology of NASH, and a predicted prevalence of 35% of the adult population worldwide, has prompted drug development programs aimed at multiple targets across all stages of the disease
Previous studies, aimed at screening anti-DMG therapeutics, often focused on investigating drug efficacy without considering drug penetration across the BBB 42,43 However, the tightness and high selectivity of the BBB, specifically in the pons, prevent the majority of drug compounds from reaching the tumor site 13 Therefore, taking into consideration drug permeation during investigations of drug efficacy, as enabled by our BBB-tumor system, helps to better predict the potential success of new compounds
Most published outcomes are measured at 26 weeks (Phase 2) or 68 weeks (Phase 3 REDEFINE)
Craig: It's still very common
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