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Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans

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Metabolic disruption also extends to thrombotic mechanisms: platelet activation requires a glycolytic ATP surge mediated by HK2 and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), while hyperglycemia stiffens clots via advanced glycation end-product (AGE) crosslinking

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