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Ye F, Chai W, Xie M, Yang M, Yu Y, Cao L, et al

7.1.1 High-throughput screening and multi-omics integration 7.1.1.1 Single-cell resolution technologies Single-cell transcriptomics (scRNA-seq) and chromatin accessibility sequencing (ATAC-seq) enable unprecedented cell-type-specific analysis of EED-induced epigenetic and transcriptional alterations (119)

Santn-Mrquez et al., 2019), reduce beta-amyloid and tau production (Kim, 2021), increase brain derived neurotrophic factor (Kim et al., 2017), postsynaptic density protein 95, AMPA receptor 1 (GluA1), dendritic spine density (Zhang et al., 2017), and blood brain barrier integrity (Li et al., 2013)

Thus, late compared to early-onset depression may be associated with greater AD pathology