A study published in PMC examining chemical intolerance and mast cell activation found that alterations in the redox system, glutathione depletion, and pro-inflammatory cytokines interact to affect mast cell behavior. 13 When glutathione is depleted, oxidative stress increases, which can trigger mast cell activation through multiple pathways
7,8 The amino acid cysteine, a component of glutathione, is rate-limiting for glutathione synthesis and itself acts as a direct antioxidant in plasma
Malekshah OM, Sarkar S, Nomani A, Patel N, Javidian P, Goedken M, et al
Note: frequently the term DMARD is used to refer to the non-biologic subclass of these drugs, and biologics is used to refer to biologic DMARDs
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