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Limited long-term human safety data for most compounds, with evidence generally drawn from short trials, animal studies, or research on a different indication

In research settings, it is studied for its involvement in angiogenesis, cellular repair mechanisms, and the modulation of inflammatory pathways in experimental systems

Leaving reconstituted solution on a counter, in a warm car, or in a bag exposed to body heat meaningfully shortens effective shelf life

The body cannot produce B12 itself and relies on dietary intake, primarily from meat, fish, eggs and dairy

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