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Xie JL, Grahl N, Sless T, Leach MD, Kim SH, Hogan DA, et al

Physiological assessment of airway function demonstrated that only vehicle-treated ILC2s induced airway hyperreactivity, whereas melatonin-treated ILC2s prevented the development of AHR following IL-33 challenge ( Figures 4IJ )

7.6 Integrative perspective and future outlook Taken together, both antioxidant-based and EV-based interventions face shared translational limitations rooted in model relevance, standardization, and clinical validation

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The interaction is facilitated by the microbiota, but a dysbiotic biota can lead to brain inflammation and psychopathologies as depicted in Figure 6 (86, 87)