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Fluorescence lifetime imaging of physiological free cu(II) levels in live cells with a cu(II)-selective carbonic anhydrase-based biosensor

[1] The clinical significance lies not in direct vitamin toxicity, but rather in what elevated levels may indicate about underlying health conditions

Under physiological conditions, autophagy plays a protective role in maintaining cellular homeostasis and may induce cell death only when it is excessively activated or when the autophagic flux is blocked

While Se is an essential element for humans, it can be toxic at high levels [306]

Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor: tropomyosin-related kinase B in hippocampus of obesity-induced hypertensive rats