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[6], [7] Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most prevalent chronic liver disorder worldwide, with an increasing incidence driven by the global rise in obesity and metabolic syndrome

The current landscape of understanding, primarily based on limited clinical data and anecdotal experiences, calls for a more comprehensive and systematic approach to safety evaluation

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(2016) identified endogenous LPLA2 in three purified monoclonal antibody products at concentrations less than 1 ppm