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While exploration of PE-22-28 itself remains limited, the growing body of Spadin-based research has positioned it as a compound of scientific interest

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reviewed by Hassan and Aarts, 2011 and Mehes-Smith et al., 2013)

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Therefore, this section focused on the progress of clinical trials for treating amino acid metabolism in diseases

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Compound 16 (Figure 16) exhibited the highest inhibitory efficacy against NO (IC 50 = 7.70 M) and showed no notable toxicity

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