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Melatonin as an antioxidant, among other actions, directly neutralizes free radicals and ROS, stimulates the synthesis of antioxidant substances such as nitric oxide and glutathione, increases the activity of antioxidant enzymes such as glutathione peroxidase, superoxide dismutase (SOD2) and catalase, inhibits the activity of oxidative enzymes, and protects the function of mitochondria by increasing the activity of the transport chain and preventing depolarization of the mitochondrial membrane [30,33]

No standardized therapeutic dosage has been established

This approach guarantees a reduction in melanin production, leading to visibly brighter skin

Hence, pathways and mechanisms need to be investigated for possible pharmacological intervention

Yao J, Li Z, Fu Y, et al