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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)

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10.1111/j.1399-0039.2008.01178.x Summary Keywords allopurinol, stevens-johnson syndrome, adverse drug reaction, HLA-B*58:01, pharmacogenetics, severe cutaneous adverse reactions Citation Ferdiana A, Fachiroh J, Oktarina DAM, Irwanto A, Mahendra C, Febriana SA and Soebono H (2022) Allopurinol-Induced StevensJohnson Syndrome in Javanese Men With Positive HLAB*58:01

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Liu T, Liu W, Zhang M, Yu W, Gao F, Li C, et al