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Binding of cGAMP induces a conformational change that facilitates oligomerization of STING dimers and STING activation ( Active STING is translocated from the ER to the ER-Golgi intermediate compartment (ERGIC) and Golgi via COPII vesicles, which requires secretion-associated and Ras-related GTPase 1A (SAR1), SEC24 homolog C (SEC24C) and ADP-ribosylation factor (ARF) family members ( At the Golgi and in post-Golgi compartments, TBK1 is recruited and then activated by STING ( Figure 2 )

In the 2-cell embryo, GPx3 formed clusters also under the cytoplasmic membrane (CPM)

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Nature 596 , 211220 (2021)

It is largely contained in various food sources, including coffee, tea, nuts, olive oil, and beer [88]