glutathione sulforaphane Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Metabolism of 4-methylsulphinylbutyl glucosinolate and

Journal of the American Dietetic Association

Other risks encompass hormonal imbalance, potential immune responses, injection-site complications, and unidentified long-term consequences

doi: 10.21203/rs.3.rs-1796347/v1 93 VillaTSnchez-PrezA

Anti-Inflammatory Activity: The peptide suppresses the production of pro-inflammatory cytokines, including TNF-, IL-6, and TGF-1 (when overexpressed), while also reducing oxidative damage

Disruption in iron homeostasis, including increased transferrin receptor expression and ferritin degradation via NCOA4-mediated ferritinophagy, contributes to ferroptotic susceptibility ( Lipid Peroxidation: Polyunsaturated fatty acids (PUFAs), especially arachidonic and adrenic acids, are substrates for lipoxygenases (LOX), which drive peroxidation in membrane phospholipids, generating cytotoxic lipid peroxides such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) ( Glutathione Depletion and GPX4 Inactivation: System Xc imports cystine for GSH synthesis