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Antioxidants, 2020

Methods We examined the general health check-up data and claim database of the Korean National Health Insurance Service (NHIS) of 2,668,615 participants with type 2 diabetes mellitus who had examinations between 2009 and 2012

Circulating IGF-1 levels vary depending on the persons age: there is initially an increase in serum IGF-1 from birth to puberty, followed by a stable decline with age in response to the lower GH levels [9,10]

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Excessive ROS generation interferes with insulin signaling by impairing insulin receptor substrate phosphorylation and promoting inflammatory kinase activation, thereby favoring insulin resistance