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Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

Erastin can directly bind to VDAC 2 and alter mitochondrial membrane permeability, thereby inducing nonapoptotic cell death [48]

Further studies in human cells revealed that LONP1 does not directly regulate the protein abundance of HSP60 or mtHSP70 but instead influences apoptosis by modulating the stability of the HSP60mtHSP70 protein complex [47, 48]

Yanamandra U, Das R, Malhotra P, Varma S (2018) A case of autosplenectomy in sickle cell trait following an exposure to high altitude