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Sustained oxidative stress and inflammatory cytokine release driven by elevated SUA may upregulate and enhance the expression and activity of matrix metalloproteinases (MMPs) in vascular wall cells, particularly macrophages and vascular smooth muscle cells

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Dupilumab combined with methylprednisolone and azathioprine demonstrated benefits in managing the progression of the disease and expediting the decrease in glucocorticoid dosage (218)

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