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Glycine import is especially important in red cells, as ALAS2, the predominant ALAS isoform in erythroid cells, has a very high K m (9.3 1.2 mM), requiring adequate levels of glycine in the mitochondrial matrix for heme synthesis

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However, research is also needed on the efficacy and cost-effectiveness of different strategies to facilitate long-term WL maintenance for example the use of lower medication doses or the less frequent dosing of obesity pharmacotherapy for WL maintenance