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As noted above, 5-cholesten-3-one is not showing any activity with the mammalian enzymes, presumably due to steric hindrance by the bulky sidechain (Figure 8)

In a regenerative care conversation, that profile may become relevant when recovery, soft-tissue strain, digestive resilience, or healing support becomes part of the larger clinical picture

Long-term safety data in humans is lacking

A general overview of each member is provided in Table 1 and Figure 3, whereas new insights about certain members are discussed in Section Distinct HSP70s