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Therefore, as in the case of ROS, low and regulated production of NO is associated with paracrine signaling processes whereas its overproduction can cause damage to biological macromolecules and determine many pathological states [18,23,35]
On the other hand, bioinformatics models have been developed to predict the functional potential of individual phosphosites [112]
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Activation of the NLRP3 inflammasome increased ROS generation with a loss of mitochondrial membrane potential and mitochondrial integrity in human microglial cells, independent of virus replication
In addition, the prevalence of CHIP was shown to be higher in the general population in subjects with relatively short LTLs, including males, who are known to have shorter LTLs than females, and elderly, who have shorter LTLs than younger individuals
