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Because tumor growth also depends on new blood vessels, several reviews describe this as a theoretical concern that has not been resolved in humans (Sehgal et al., Pharmaceuticals, 2025)

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This usually occurs in individuals with underlying digestive conditions, those who have trouble absorbing all nutrients through digestion, or those with pernicious anemia, which specifically prevents B12 absorption

Hormonal Side Effects: Disruption of natural hormone production can lead to a host of endocrine issues

Other possible factors include changes in posture and muscle tension, or circadian changes in stress hormone levels