Already early on, Cyrus Levinthal conceptualized the key problem facing the protein and the prediction algorithms: 152 the vast time scales for the protein to search the folding space and reach its most stable native state under biological conditions
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For peripheral nerve analysis, a 5-mm-long piece of tail 15 mm distal from the tail base was collected from each sacrificed animal, fixed in 4% formaldehyde in phosphate buffer (pH 7.4), decalcinated, and impregnated with 1% osmium tetroxide for a few days
Doctors must watch patients closely to adjust doses and handle any side effects
All dose ranges above are extrapolations from preclinical literature, not validated human clinical protocols
