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The French diplomat Jean Nicot used a tobacco poultice as an analgesic, and Nicols Monardes advocated tobacco as a treatment for a long list of diseases, such as cancer, headaches, respiratory problems, stomach cramps, gout, intestinal worms and female diseases

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Big Tobacco is known to fund distracting research that can divert attention from findings it does not like, and to use its influence to design studies in a way that can obscure unfavourable evidence, according to Malone

Alongside nicotine, e-liquids contain a mixture of flavorings, ranging from traditional tobacco flavors to an extensive array of fruit, dessert, and beverage options, catering to individual preferences