In real physiology, the bigger driver is cellular decision-making
In general, the secretion of synuclein in degenerating neurons is greatly increased compared with that of healthy neurons, and alpha-synuclein has enhanced immune characteristics when oxidized or nitrated
Panza et al., 2019
Considering that kidney and brain dysfunction share common pathogenic factors, such as vascular endothelial injury, oxidative stress, and inflammation activation, we speculate that finerenone may achieve the cognitive preservation by suppressing the production of ROS and pro-inflammatory cytokines, and could improve cerebral microvascular function by alleviating endothelial dysfunction
Two of the most famous peptides are insulin and semaglutide, a GLP-1 , says Florence Comite, MD, a longevity expert and author of the book Invincible: Defy Your Genetic Destiny to Live Better, Longer