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The causal chain of events linking smoking to genetic damage To answer the first question, let us consider the causal chain of events linking smoking to genetic damage: Emission of carcinogenic toxicants leads to exposure to carcinogenic toxicants, which in turn leads to metabolic responses to toxicant exposure, genotoxicity, and DNA damage

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Knocking down MSK1 inhibited CSE-induced posttranslational modifications of histones and the transcription of pro-inflammatory genes [57]