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2.5.2 Covariate model The influence of potential covariates on tacrolimus PK variability, including age, sex, height, body weight (WT), fat-free mass, grafted hepatic weight, hematocrit (HCT), albumin (ALB), aspartate aminotransferase (AST), total serum bilirubin (TBIL), creatinine clearance, POD, concomitant medications, and CYP3A5*3, CYPP3A4*1G, SUMO4, and NR112 genetic polymorphisms in both donors and recipients, was investigated

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Consequently, the autonomic nervous system may not be forced to trigger compensatory tachycardia, potentially leading to a stabilization of heart rate and blood pressure

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Y.LiuY.et al (2010)