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It may also be associated with the development of psychosis in certain individuals

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We have shown that decisions in reward-based foraging are modulated by the cholinergic neurotransmission of the VTA, with a particular role of nicotinic acetylcholine receptors in directed exploration, driven by expected uncertainty 33

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High-risk alcohol use was significantly associated with decreased odds of motivation to quit ( p = 0.02) and making a quit attempt ( p = 0.004)