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The approval is backed by results from the Phase IIb/III QUASAR study, in which participants given 200 mg of Tremfya every four weeks saw clinical remission at 44 weeks, compared with 19% in the placebo group
Experimental designs vary between laboratories
Some researchers inject daily with much lower doses (e.g., 1 to 2 mg per day instead of 7 mg weekly)
VGF has been reliably implicated in well powered multi-omic AD studies, with CSF 10,43,51,52 and cortical 6,11,12,13,18 depletion of VGF associated with AD and other dementia-types
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