High ROS induce NF-B signaling activation, up-regulate inflammatory cytokines (TNF-, IL-1) which promote inflammation, and further induce the abnormal expression of VEGF, induce abnormal angiogenesis (74)
Vascular Endothelial Growth Factor (VEGF) Upregulation: VEGF is the primary driver of angiogenesis (the formation of new blood vessels), essential to delivering oxygen and nutrients to healing tissue
Forrest Health, Inc
This isn't dangerous, but intradermal administration produces erratic absorption and localized irritation because the dermis lacks the vascular and lymphatic network that governs SubQ pharmacokinetics
Free Radic Biol Med 68:2234 Seet RC, Lee CYJ, Lim EC, Quek AM, Huang H, Huang SH, Halliwell B (2011) Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels