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The liver, which is the biggest organ of the body produces them

Chlorogenic acid inhibits cholestatic liver injury induced by -naphthylisothiocyanate: involvement of STAT3 and NFB signalling regulation

doi: 10.1038/ng.2901, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 47.Mancina RM, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, et al

To maintain results, additional maintenance sessions are needed, as the body will eventually break down the glutathione over time

Proc Natl Acad Sci 95(18):1044310448 Loboda A et al (2008) Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities