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10.1038/s41418-018-0124-5 66 LeiL.YuanJ.DaiZ.XiangS.TuQ.CuiX.et al (2024)

Additionally, environmental stressors like heavy metals and pesticides have been shown in experimental models to impair proteasome function, promote syn aggregation, and drive dopaminergic neuron loss, underscoring the multifaceted contribution of UPS impairment to PD pathogenesis [170]