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Despite some showing nootropic efficacy in animal models or in subjects with cognitive dysfunction (often as a result of dietary deficiencies), these were similarly found to be without effect

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Epidemiological studies show that smokers, both current and former, experience menopause up to 4 years earlier than non-smokers, with a clear dose-response pattern in heavy smokers ( Key agents like polycyclic aromatic hydrocarbons (PAHs) bind to aryl hydrocarbon receptors (AhR) in ovarian cells, activating apoptotic cascades and promoting follicular depletion