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Several researchers believe that CFS is a mitochondrial disease in which excessive, uncontrolled production of nitric oxide damages proteins in the mitochondria, and particularly in the electron transport chain

You can also get it from supplements, but most of it is broken down by enzymes in the gut into amino acids, such that only long-term use of large amounts (500 mg or more) appears to modestly raise glutathione levels

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in turn, altered gut flora can also affect thyroid function

Assessing the antioxidative status in critically ill patients