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277 Abnormal NAD + metabolism in the pathophysiological condition Given the essential regulatory role of NAD + in fundamental physiologies, NAD + metabolic abnormalities contribute to the pathophysiology of various diseases, such as infection, cancers, metabolic diseases, aging and age-associated neurodegeneration disorders

GYY4137, an H2S slow-releasing donor, prevents nitrative stress and -synuclein nitration in an MPTP mouse model of Parkinsons disease

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