glutathione s-transferase a1 The role of S-transferases in human disease pathogenesis and their current inhibitors Mechanistic evaluation and transcriptional signature

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In recent years, involvement of GSTs in different processes such as modulation of cell signaling kinases, formation and modulation of ion channels, oxidation-reduction reactions, and the post-translational glutathionylation of proteins have been outlined (Dixon et al., 2010)

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The conjugation of glutathione on the previously hydrophobic-toxic substrate results in a soluble compound, which is more readily exocytosed by the cell

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