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Loss-of-function mutations in lysosomal proteins, as seen in Niemann-Pick disease type C1 and Gaucher disease, disrupt lipid and cholesterol metabolism and result in profound neurodegeneration

The severity of symptoms varies wildly

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Reduccin del tejido adiposo y oxidacin de grasas : Gracias a su influencia en la sealizacin de la hormona del crecimiento, esta combinacin de pptidos estimula la liplisis y la movilizacin de cidos grasos, a la vez que inhibe la lipognesis

The structural modification of DNA nucleosides by nonenzymatic glycation: an in vitro study based on the reactions of glyoxal and methylglyoxal with 2-deoxyguanosine