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Studies have found elevated levels of autoantibodies targeting key receptors, such as ACE2 (the primary receptor for SARS-CoV-2), 2-adrenoceptors, muscarinic M2 receptors, angiotensin II AT1 receptors, and angiotensin 17 MAS receptors [73,74,75]

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For retatrutide , phase 2 data published in the New England Journal of Medicine (2023) demonstrated substantial mean weight reductions over 48 weeks in adults with obesity among the highest figures reported for any pharmacological agent to date